Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution

João M C de Assis,Eduardo J Barbosa,Vinícius D N Bezzon,Felipe R Lourenço,Flavio M S Carvalho,J R Matos,Nadia Araci Bou-Chacra,Chris J Benmore,Stephen R Byrn,Fanny N Costa,Gabriel L B de Araujo

International Journal of Pharmaceutics（2022）

引用 8|浏览6

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摘要

•Flubendazole amorphous solid dispersions were hot-melted extruded.•Copovidone, magnesium stearate and hydroxypropylcelullose were evaluated.•Mixtures statiscally designed were extruded in a twin-screw extruder.•Flubendazole:copovidone was highly extrudable, except when drug load was >40%.•Extruded materials had improved dissolution results compared with pure drug.

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关键词

Flubendazole,Copovidone,Hydroxypropyl cellulose,Magnesium stearate,Hot-melt extrusion,Amorphous solid dispersion,Dissolution

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