Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder

Sarah A. Keim, Abigail Jude,Katie Smith,Aiman Q. Khan,Daniel L. Coury,Joseph Rausch,Shivika Udaipuria,Megan Norris,Lindsay R. Bartram, Anita R. Narayanan,Lynette K. Rogers

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS（2022）

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Abstract

This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6 years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90 days based on participant weight. Erythrocyte FAs and the cytokines, IL-1β, IL-2, IFNγ, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40 mol

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Key words

Autism spectrum disorder,IL-2,Inflammation,Omega-3 fatty acids,Omega-6 fatty acids,Young child

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