Neurophysiological mechanisms of cancer-induced bone pain

•The development of scientific research in CIBP was elaborated in a complete and clear perspective.•The possible mechanisms, including the new achievements in central sensitization, glial cell activation, acid environment, of CIBP were reviewed.•Several key molecules and treatments as well as the potential targets and promising therapies were also briefly reviewed.•The challenges we faced and the future directions are also summarized and elaborated.