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Characteristics of sensory innervation in synovium of rats within different knee osteoarthritis models and the correlation between synovial fibrosis and hyperalgesia

Li Zhang,Mingchao Li,Xiaochen Li,Taiyang Liao,Zhenyuan Ma,Li Zhang,Runlin Xing,Peimin Wang,Jun Mao

Journal of Advanced Research（2022）

Cited 20|Views8
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Abstract
•Synovial fibrosis was positively correlated with pain sensitivity in KOA rats.•Synovial fibrosis was most prominent in DMM group 14 days after modeling.•ACLT replaced DMM to be the most typical at 28 days after modeling.•Increased synovial sensory innervation followed the same trend as fibrosis.•ACLT is more applicable for KOA pain research.
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Key words
Knee osteoarthritis,Animal models,Pain,Synovial fibrosis,Sensory innervation
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