Venetoclax enhances NK cell killing sensitivity of AML cells through the NKG2D/NKG2DL activation pathway

Hui-Yang Wu,Ke-Xin Li,Wan-Ying Pan,Meng-Qi Guo, Dei-Zhi Qiu,Yan-Jie He,Yu-Hua Li,Yu-Xian Huang

International Immunopharmacology（2022）

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摘要

•BCL2 inhibitor venetoclax can enhance the efficacy of NK cells against AML.•The synergistic effect of combining venetoclax with NK cells resulted from the NKG2D/NKG2DL immune ligand receptor pathway activated by venetoclax.•NFKB signaling pathway involved in venetoclax-induced NKG2DL expression.

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关键词

Acute myeloid leukaemia,NK cell immunotherapy,natural killer group 2 member D (NKG2D),BCL2 inhibitor,Venetoclax

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