Changing characteristics, treatment approaches and survival of patients with brain metastasis: data from six thousand and thirty-one individuals over an observation period of 30 years

•Higher prevalence of asymptomatic brain metastasis (BM) in over time.•Increase of BM free survival in some primary tumour entities.•Significant changes of BM treatment patterns during observation period.•Survival times of patients with BM depend on primary tumour molecular profiles.•Importance of entity-specific treatment approaches in planning of clinical trials.