Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain.

Jose R Robador,Manuel J Feinauer,Stefan W Schneider,Frank T Mayer,Christian Gorzelanny, Artur Sacharow,Xiaobo Liu,Anna Berghoff,Maria A Brehm,Daniela Hirsch, Julia Stadler, Sabine Vidal-Y-Si,Ewa Wladykowski,Marisse Asong,Kai Nowak,Marcel Seiz-Rosenhagen,Viktor Umansky,Christian Mess,Klaus Pantel,Frank Winkler,Alexander T Bauer

Neuro-oncology advances（2021）

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摘要

Our data indicate that platelet-derived VWF is involved in cerebral clot formation and in metastatic growth of melanoma in the brain. Targeting platelet activation with low-molecular-weight heparins represents a promising therapeutic approach to prevent melanoma BM.

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关键词

melanoma,metastasis,platelets,thrombosis,von Willebrand factor

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