Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells

•Cellular senescence is associated with ageing and multiple age-related disorders where it contributes to the pathological manifestations.•Senotherapies have recently shown great promise in multiple pre-clinical disease models, and are being tested in clinical trials.•Despite promising proof-of-principle evidence, there are toxicities associated with these compounds, thereby limiting their translatability and clinical applications.•Galacto-conjugation of a variety of modular systems and compounds is a versatile therapeutic and detection strategy to facilitate preferential targeting of senescent cells .•Senotherapies and detection tools are expected to impact precision medicine in human settings over the next few years.