Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source
Chemical Communications(2022)
摘要
Herein, we report a cobalt-catalyzed α-hydroxymethylation of amides with methanol under mild conditions. Using CoCl2·6H2O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides were obtained in moderate to excellent yields. The developed method features a wide substrate scope and good functional group tolerance. In addition, anticholinergic tropicamide was easily synthesized in this way.
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关键词
methanol,amides,c1 source,cobalt-catalyzed
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