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High affinity monoclonal antibody targeting Siglec-15 for cancer immunotherapy.

Fei He,Na Wang, Jiangwei Li,Luanying He,Zhao Yang,Jiandong Lu,Guoliang Xiong,Changyuan Yu,Shihui Wang

Journal of clinical and translational research（2021）

Cited 3|Views7
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Abstract
The anti-Siglec-15 mAb prepared in this study is useful as an immune checkpoint inhibitor against Siglec-15 for normalization cancer immunotherapy. This immunotherapy provides an alternative treatment for cancer patients who are refractory to the well-known PD-L1/PD-1-targeting therapies.
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Key words
Siglec-15,cancer immunotherapy,fluorescent-activated cell sorting,hybridoma cell,monoclonal antibody
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