Region-specific effects of antenatal/early postnatal hypothyroidism on endothelial NO-pathway activity in systemic circulation.

Dina K Gaynullina,Svetlana I Sofronova,Ekaterina K Selivanova,Anastasia A Shvetsova,Anna A Borzykh,Olga S Tarasova

Current research in physiology（2022）

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摘要

Antenatal/early postnatal hypothyroidism is followed by an increase in NO-mediated anticontractile influence in sural, but not in mesenteric arteries of adult animals. The diversity of hypothyroidism effects may be due to different alterations of local T3 synthesis/reception in different vascular beds.

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关键词

Deiodinase 2,Maternal hypothyroidism,Nitric oxide,Small arteries,Thyroid hormone receptor α

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