CRISPR/Cas12a Collateral Cleavage Activity for an Ultrasensitive Assay of RNase H
CHEMICAL COMMUNICATIONS(2022)
Abstract
We herein describe an ultrasensitive RNase H assay by utilizing CRISPR/Cas12a collateral cleavage activity. Based on this unique design principle, the RNase H activity was successfully determined down to 0.00024 U mL-1, which is quite superior to those of alternative approaches.
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CRISPR Systems
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