A Prospective Cohort Study of Novel Markers of Hepatitis B Virus Replication in Human Immunodeficiency Virus Coinfection

Raymond T Chung,Wendy C King,Marc G Ghany,Mauricio Lisker-Melman,Amanda S Hinerman,Mandana Khalili,Mark Sulkowski,Mamta K Jain,Eun-Young K Choi,Michael A Nalesnik,Atul K Bhan,Gavin Cloherty,David K Wong,Richard K Sterling

Clinical Gastroenterology and Hepatology（2023）

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摘要

In HBV-HIV coinfected adults on suppressive dually active antiviral therapy, the use of novel HBV markers reveals continued improvement in suppression of HBV transcription and translation over time. The lack of further improvement in HBV serum biomarkers among HBeAg- patients suggests limits to the benefit of combination anti-viral therapy and provide rationale for additional agents with distinct mechanisms of action.

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关键词

HBcrAg,HBV,HBV RNA,HIV,Serum Biomarkers

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