The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus

Shan Zeng,Qian Qiu,Yi Zhou,Youjun Xiao,Jingnan Wang,Ruiru Li,Siqi Xu,Maohua Shi,Cuicui Wang,Yu Kuang,Minxi Lao,Xiaoyan Cai,Liuqin Liang,Hanshi Xu

International Immunopharmacology（2022）

引用 1|浏览15

暂无评分

摘要

•Brd4 inhibition suppresses peripheral plasma cell differentiation.•Brd4 is involved in regulating BLIMP1 expression, a critical transcript that controls plasma cell differentiation.•Brd4 inhibition attenuates nephritis, reduces hypergammaglobulinemia and plasma cells in lupus mice model.

查看译文

关键词

Bromodomain-containing protein 4,B cell, plasma cell,Systemic lupus erythematosus

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要