Platelet glycoprotein Ibα provides radiation protection

Adam Corken,Sanchita P. Ghosh,Ruofei Du,Marjan Boerma,Jerry Ware,Rupak Pathak

Radiotherapy and Oncology（2022）

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摘要

•Platelet glycoprotein Ibα (GPIbα) dysfunction enhances radiation lethality in mice.•GPIbα dysfunction reduces platelet–leukocyte aggregation before/after irradiation.•GPIbα dysfunction increases monocyte activation and gut damage following radiation.•GPIbα dysfunction increases serum cytokine levels following radiation.

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关键词

CD,GP,IL,IR,KC,Mac-1,MCP-1,MFI,MIP-1β,MSA,SEM,TBI,TNFα,TPO,VWF,WT

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