Focus Ultrasound-Induced Blood-Brain Barrier opening enhances anti-pGlu3 Aβ mAb delivery and amyloid-beta plaque clearance.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2021)
Abstract
Transient opening of the BBB by FUS increased 07/2a delivery to the brain, improved cognition, and enhanced Ab clearance in aged APP/PS1dE9 mice, suggesting that FUS increased efficacy of the 07/2a mAb.
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