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Focus Ultrasound-Induced Blood-Brain Barrier opening enhances anti-pGlu3 Aβ mAb delivery and amyloid-beta plaque clearance.

Praveen Bathini,Tao Sun,Qiaoqiao Shi,Yongzhi Zhang,Nadine Taudte,Mathias Schenk,Thore Hettmann,Stephan Schilling,Nathan McDannold,Cynthia A Lemere

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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Abstract
Transient opening of the BBB by FUS increased 07/2a delivery to the brain, improved cognition, and enhanced Ab clearance in aged APP/PS1dE9 mice, suggesting that FUS increased efficacy of the 07/2a mAb.
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