Atg1 kinase activity links PAS dissolution to balanced Atg8 conjugation
TRENDS IN CELL BIOLOGY(2022)
Abstract
Atg1 phosphoregulates different steps and factors in autophagy. Schreiber et al. report in Molecular Cell on the cell-free identification of a negative feedback ejection of Atg1 from the pre-autophagosomal structure (PAS), followed by positive feedback recruitment of Atg1 to phagophore-resident Atg8-PE, followed by yet another, negative feedback inhibition of the Atg8 conjugation machinery.
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Key words
Atg1 kinase,Atg8-PE,autophagosome,macroautophagy,pre-autophagosomal structure
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