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H3.3 safeguards haematopoietic ERV-quilibrium

Nadia Omega Cipta,Ying Chen,Yuin-Han Loh

NATURE CELL BIOLOGY（2021）

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Abstract
Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterations.
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Key words
Epigenetics,Haematopoietic stem cells,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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