Trapping Reactions of Benzynes Initiated by Intramolecular Nucleophilic Addition of a Carbonyl Oxygen to the Electrophilic Aryne
Organic Letters(2022)
摘要
We describe here reactions in which a carbonyl oxygen atom initiates cascade reactions by nucleophilic attack on a covalently attached benzyne. The benzynes are produced by thermal cyclization of triynes via hexadehydro-Diels–Alder reaction. The initially produced oxocarbenium/aryl carbanionic zwitterion is protonated in situ by an external protic nucleophile (NuH) of appropriate acidity. The resulting ion pair (oxocarbenium+/Nu–) collapses through several different mechanistic manifolds, adding to the diversity of structural classes that can be generated.
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关键词
benzynes initiated,electrophilic aryne,intramolecular nucleophilic addition,carbonyl oxygen,reactions
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