Altered gut microbiota in Parkinson's disease patients with motor complications

Kai Takahashi,Hiroshi Nishiwaki,Mikako Ito,Kazuhiro Iwaoka,Kenta Takahashi,Yoshio Suzuki,Keita Taguchi,Kanako Yamahara,Yoshio Tsuboi,Kenichi Kashihara,Masaaki Hirayama,Kinji Ohno,Tetsuya Maeda

Parkinsonism & Related Disorders（2022）

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摘要

•We enrolled 223 Parkinson's disease (PD) patients from four centers in Japan (76/85).•We employed 16S ribosomal RNA gene sequence analysis for gut microbiota (71/85).•Lachnospiraceae Blautia abundance is decreased in PD patients with wearing-off (78/85).•Lactobacillaceae Lactobacillus abundance is increased in PD patients with wearing-off (85/85).

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关键词

Gut microbiota,Motor complications,Parkinson's disease,Dyskinesia,Wearing-off

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