卒中后中枢痛胶质细胞的作用和分子机制

Journal of Apoplexy and Nervous Diseases(2021)

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Abstract
中枢性卒中后疼痛(central post stroke pain,CPSP)是一种脑血管意外后的慢性神经性疼痛综合征[1],多在出血或缺血性脑卒中后6个月出现,CPSP约占卒中患者发病率的1%~14%[2],由相应的缺血或出血性病变影响脊髓丘脑通路而引起的神经性疼痛综合征[3],发病机制尚不清楚.其临床特征通常表现为感觉障碍、持续性或间歇性疼痛以及痛觉过敏、超敏,且缺乏有效治疗手段[4].
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