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4-羟基芝麻素通过抑制p38 MAPK/NLRP3信号通路减轻BV2小胶质细胞神经炎症损伤

倪林,张庆,张小琴,黄贞伟,林埔

Chinese Pharmacological Bulletin（2021）

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Abstract
4-羟基芝麻素(4-hydroxysesamin)属于双四氢呋喃木脂素类成分,存在于叶下珠、黄荆、香樟等中药中.以芝麻素为代表的双四氢呋喃类成分具有抗肿瘤、抗脑卒中等作用[1 -2],但有关4-羟基芝麻素对神经炎症反应的抑制作用及可能机制未见报道.
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