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伊马替尼致慢性粒细胞白血病患者玻璃体及眼底出血1例分析

WU Na,Qi Lin,CHENG Zhiyong,DING Yueling,ZHOU Xiaodai,XIE Yangyang,ZHAO Yaling

Cancer Research on Prevention and Treatment（2021）

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Abstract
0? 引言 慢性粒细胞白血病(chronic myelogenous leu-kemia, CML)为造血干细胞恶性克隆性疾病,其发病及进展缓慢,据病程分为三期:慢性期、加速期和急变期.CML的特征改变是染色体形成9, 22号染色体易位,形成BCR-ABL融合基因,其蛋白产物具有酪氨酸激酶活性,从而导致CML的发生[1].伊马替尼 (imatinib)为酪氨酸激酶抑制剂,能够特异性的抑制BCR-ABL蛋白活性,为治疗CML的首选靶向药物[2].伊马替尼的应用极大改善了CML患者的生存及预后.
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