PI3 K/Akt/mTOR信号通路与多囊卵巢综合征患者子宫内膜癌的发生机制研究
Modern Journal of Integrated Traditional Chinese and Western Medicine（2021）
Abstract
多囊卵巢综合征( polycystic ovary syndrome, P-COS)是集生殖障碍与代谢异常于一身的内分泌代谢性疾病,是育龄期女性无排卵性不孕的主要原因.患者常出现内分泌代谢紊乱,约75％的PCOS患者伴有胰岛素抵抗( insulin resistance,IR)和高胰岛素血症(hyperinsulinemia,HI)[1].子宫内膜癌(endo-metrial cancer,EC )在女性癌症发病率中高居第6位,占比5％ [2].多囊卵巢综合征( PCOS)通常被认为是发展为Ⅰ型子宫内膜癌的一个重要的风险因素[3].
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