Efficient Oxidative Coupling of Isochroman with Primary Arylamines Catalyzed by Heterogeneous Ni-Containing Layered Double Oxide

An efficient heterogeneous catalytic system based on NiGa layered double oxide (Ni3Ga-LDO) for the C-N coupling between isochroman and primary arylamines has been described. Various primary aiylamines were tolerated by the catalytic system, and good to excellent yields for the corresponding coupled products could be obtained. The results indicated that Ni species played the key role in the oxidative cross-coupling process, and the catalyst had good catalytical and structural stability. The protocol provides an effective alternative approach to construct C-N bond.