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肠道菌群驱动巨噬细胞糖代谢重编程与动脉粥样硬化“脾虚痰瘀”

战凯璇,陈丽娟,贾连群,吕美君,隋国媛,杨关林,曹媛,杜莹,曹慧敏,宋囡

Chinese Archives of Traditional Chinese Medicine（2021）

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Abstract
脾主运化,为气血生化之源.脾失健运,痰瘀互结,瘀滞日久,脉道不利,最终引发动脉粥样硬化(atherosclerosis,AS)发生.中医认为维持肠道菌群稳态是脾主运化的重要生理功能.肠道菌群作为人体内具有生物屏障、营养、免疫等多种生物学作用的重要“器官”,其稳态失衡,将影响人体正常健康状态,其机制可能为肠道菌群失调诱导脂多糖(lipopolysaccharide,LPS)释放驱动巨噬细胞糖代谢重编程引发炎症反应继而导致AS发生.
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