病理性瘢痕形成机制的研究进展

Modern Journal of Integrated Traditional Chinese and Western Medicine(2021)

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Abstract
病理性瘢痕包括增生性瘢痕( hypertrophic scar, HS)和瘢痕疙瘩(keloid,K),是创伤、烧伤、外科手术后皮肤的一种纤维过度增生性疾病.其共同的组织学特征为成纤维细胞( fibroblast,FB)过度增生和细胞外基质( extracellular matrix, ECM )过度沉积.病理性瘢痕不仅造成损伤局部形态改变,而且瘢痕过度挛缩还可致器官功能障碍甚至功能丧失,严重危害患者的身心健康.但其发病机制复杂,诸多问题尚不清楚,其预防与治疗尚无满意的方法.现将病理性瘢痕细胞及分子生物学机制的研究进展综述如下.
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