LncRNA与成骨分化相关信号通路的研究进展
Journal of Clinical Neurosurgery(2021)
Abstract
骨骼是人体的重要支架,参与调节各种生理功能.成骨分化是一个复杂的过程,受转录因子Runx2、p57和Sp7等的严格控制,同时调控着大量关键下游促成骨靶基因的转录.长链非编码RNA(LncRNA)可促进细胞增殖,并通过复杂机制网络调控成骨标志物或关键调节因子及相关途径参与骨生成.本文主要从Wnt/β、TGF-β/BMP、PI3K/AKT等信号通路对LncRNA调控成骨分化的研究进展进行综述.
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