TGF-β1/Smads信号通路在纤维化疾病中的研究进展
Chinese Journal of Surgery of Integrated Traditional and Western Medicine(2021)
Abstract
组织器官纤维化可最终导致脏器功能发生障碍,其发生、发展机制目前尚不完全明确.而研究发现转化生长因子β1是重要的致纤维化因子,可以激活其下游Smads蛋白的表达,调控机体的纤维化进程.文章将对TGF-β1/Smads信号通路在各种纤维化疾病中的调控机制进行综述.
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