钙敏感受体激活性和失活性突变所致骨矿代谢异常疾病及治疗
Chinese Journal of Osteoporosis and Bone Mineral Research（2021）
Abstract
钙敏感受体(calcium-sensing receptor,CaSR)是感知细胞外钙离子浓度,调节甲状旁腺素分泌及尿钙重吸收,维持钙稳态的关键受体.CaSR激活性和失活性突变导致钙调定点的移动,引起相应的钙矿物质代谢异常疾病和骨代谢异常表现.本文综述CaSR突变所致疾病的发病机制、临床表现、治疗策略,通过动物实验模型阐述CaSR的病理生理功能,并探讨针对上述疾病的治疗及CaSR配体药物的研究进展.
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