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Hippo信号通路与心脏病

International Journal of Cardiovascular Disease(2021)

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Abstract
Hippo信号通路通过调控细胞分化、增殖和凋亡控制细胞和器官的大小.该通路的主要激酶STE20样激酶1/2、大肿瘤抑制基因1/2、Yes相关蛋白存在于哺乳动物心脏中,对心肌细胞的生长和死亡起着重要的调节作用,通过影响心肌肥厚、非特异性炎性反应、纤维化及细胞凋亡等,参与修复受损心肌.该文介绍了Hippo信号通路的作用.
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