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外泌体m6A修饰的环状RNA调节低氧性肺动脉高压的研究

周长喜, 周敏,夏世金,徐康乔

Chinese Journal of Lung Diseases (Electronic Edition)（2021）

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Abstract
2019年诺贝尔生理学或医学奖授予3位科学家,表彰他们开创性地揭示细胞如何感知和适应氧气供应,提出可调节基因活性以应对不同氧浓度变化的氧感应和适应性理论,诠释生物处于低氧和高氧环境所出现病理生理的分子机制[1].低氧能使机体产生系统性疾病,在肺部可表现为低氧性肺动脉高压( hypoxic pulmonary hypertension, HPH).
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