脑电图表现为δ刷的抗代谢型谷氨酸受体5脑炎一例
Chinese Journal of Neurology(2021)
Abstract
抗代谢型谷氨酸受体5(mGluR5)脑炎为一种罕见的自身免疫性抗体介导的中枢神经系统疾病,目前暂无亚洲病例报道。我院收治1例51岁男性患者,临床表现为精神障碍、癫痫及脑神经(Ⅶ)损害,视频脑电图检查可见δ刷、双侧颞区尖波及尖慢波,脑脊液及血清抗mGluR5抗体IgG阳性。患者先后接受了一线(激素、丙种球蛋白)及二线(利妥昔单抗)免疫治疗,但最终死于肺部感染所致的呼吸衰竭及心跳骤停。
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Key words
Encephalitis,Autoimmunity,Limbic encephalitis,Receptors, glutamate,Extreme delta brush
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