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DWI和动态对比增强MRI多参数鉴别腮腺Warthin瘤与多形性腺瘤

Chinese Journal of Magnetic Resonance Imaging(2021)

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Abstract
目的探讨弥散加权成像(diffusion weighted imaging,DWI)、动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)多参数鉴别诊断腮腺Warthin瘤与多形性腺瘤的价值.材料与方法回顾性分析病理学证实的24例腮腺Warthin瘤患者共32个病灶、24例多形性腺瘤的MRI及临床资料.评估患者一般资料、表观弥散系数值(apparent diffusion coefficient,ADC)、T1初始信号强度值(previous signal intensity,SIpre)、增强后最大信号强度值(maximum signal intensity,SImax)、增强期末信号强度值(signal intensity of the end of enhancement,SIend)、达峰时间(time to peak,TTP)、廓清率(wash-out ratio,WR)及时间信号强度曲线(time intensity curve,TIC)类型.用受试者工作特征(receiver operating characteristic,ROC)曲线分析组间有统计学差异的参数对Warthin瘤与多形性腺瘤的鉴别诊断效能.结果Warthin瘤发病年龄与多形性腺瘤不同,前者大于后者(t=9.33,P<0.05);男女比例不同,前者以男性为主,后者以女性多见(P<0.05).Warthin瘤ADC值[(0.634±0.201)×10-3 mm2/s]显著低于多形性腺瘤[(1.084±0.453)×10-3 mm2/s](t=-5.00,P<0.05).两者SIpre(t=4.01,P=0.0002)、WR(t=15.10,P<0.0001)、TTP(P<0.05)及TIC类型(P<0.05)差异有统计学意义.以ADC值=0.811×10-3 mm2/s为阈值,鉴别Warthin瘤与多形性腺瘤的AUC为0.845(P<0.05),敏感度为83.3%,特异度为90.63%;TIC类型区分二者的AUC为0.961(P<0.05),敏感度为95.45%,特异度为100%;ADC值与TIC类型联合区分二者的AUC为0.984(P<0.05),敏感度为100%,特异度为96.88%.结论DWI、DCE-MRI多参数及联合有助于鉴别Warthin瘤与多形性腺瘤.
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