BRCA基因突变卵巢癌的治疗进展
Clinical Medicine of China(2021)
Abstract
卵巢癌是女性生殖系统肿瘤中最为致命的恶性肿瘤,大多在晚期被诊断出来,这在很大程度上导致了卵巢癌的预后不佳。乳腺癌易感基因(breast cancer susceptibility genes,BRCA)是一种重要的DNA同源修复基因,在正常的细胞DNA修复机制中起主要作用,其突变会导致同源重组缺陷,从而影响基因组的稳定性,导致肿瘤的发生。近年来,BRCA基因检测已经成为卵巢癌风险评估、预后、治疗和预防的关键步骤。
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Key words
Ovarian cancer,Breast cancer susceptibility gene,Mutation,Treatment
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