糖尿病与卒中后认知损害

International Journal of Cerebrovascular Diseases(2021)

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Abstract
糖尿病可显著增高卒中后认知损害(post-stroke cognitive impairment, PSCI)风险。既往研究显示,糖尿病通过胰岛素抵抗、血脑屏障破坏、低度炎症、β淀粉样蛋白沉积与tau蛋白磷酸化、加重缺血性脑损伤、氧化应激反应等机制参与认知损害的发生。近年来,糖尿病在PSCI病理生理学过程中的作用日益受到关注。文章对糖尿病与PSCI的相关性以及可能的病理生理学机制进行综述,期望为糖尿病患者PSCI的防治策略提供参考依据。
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Key words
Stroke,Brain ischemia,Cognition disorders,Cognition,Diabetes mellitus
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