Paeoniflorin-6′-o-benzene sulfonate ameliorates the progression of adjuvant-induced arthritis by inhibiting the interaction between Ahr and GRK2 of fibroblast-like synoviocytes
Chinese Journal of Pharmacology and Toxicology（2022）
Abstract
•CP-25 inhibited the development of arthritis.•CP-25 inhibited the development of arthritis in AA rats, which may be related to the inhibition of Ahr expression in synovial tissue.•CP-25 may play an anti-inflammatory immune regulation effect by inhibiting the activation of Ahr and the interaction between Ahr and GRK2 in FLS.
MoreTranslated text
Key words
Aryl hydrocarbon receptor,G protein-coupled receptor kinase 2,Rheumatoid arthritis,CP-25,Fibroblasts like synoviocyte,Adjuvant-induced arthritis
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined