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2型糖尿病治疗药物托格列净的合成路线图解

文雯,宋慧颖,姚宇, 李博,胡家栋

Journal of Guangdong Pharmaceutical University（2021）

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Abstract
托格列净是一种高选择性的钠-葡萄糖协同转运蛋白2抑制剂,属于非胰岛素依赖型降糖药物,于2014年在日本上市用于治疗2型糖尿病.本文从亲核加成-直接环合法和[4+2]环加成法2个构建螺缩酮结构的角度总结了目前报道的5条托格列净合成路线的特点,以期为后期的市场化进程提供参考.
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