健脾补肾化痰中药治疗肥胖型多囊卵巢综合征疗效的meta分析
Journal of Hainan Medical University(2021)
Abstract
目的:系统评价健脾补肾化痰中药对肥胖型多囊卵巢综合征(PCOS)患者性激素及糖脂代谢的影响.方法:计算机检索中国知网、维普、万方等数据库,收集健脾补肾化痰中药联合二甲双胍治疗肥胖型PCOS的文献,使用RevMan5.3软件进行数据分析.结果:本研究共纳入11篇中文RCT文献.Meta分析结果显示联合用药能提高临床总有效率[RR=1.32,95%CI(1.20,1.45),P<0.00001],降低体重指数(BMI)[SMD=?0.92,95%CI(?1.13,?0.72),P<0.00001],黄体生成素(LH)[SMD=?1.00,95%CI(?1.37,?0.62),P<0.00001],LH/FSH[SMD=?1.03,95%CI(?1.34,?0.71),P<0.00001],空腹胰岛素(FIN)[SMD=?0.77,95%CI(?1.19,?0.35),P=0.0003],胰岛素抵抗指数HOMA-IR[SMD=?0.59,95%CI(?0.79,?0.40),P<0.00001],甘油三酯(TG)[SMD=?0.60,95%CI(?0.83,?0.36),P<0.00001],总胆固醇(TC)[SMD=?0.63,95%CI(?0.88,?0.38),P<0.00001],高密度脂蛋白(HDL)[SMD=?0.41,95%CI(?0.51,?0.32),P<0.00001];但是对腰臀比(WHR)、促卵泡生成素(FSH)、空腹血糖(FBS)、低密度脂蛋白(LDL)无明显优势.结论:健脾补肾化痰中药联合二甲双胍能改善肥胖型PCOS患者性激素及糖脂代谢,其疗效优于二甲双胍单用.
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