Synthesis of Poly-substituted 2-Hydroxycyclobutanones via Norrish–Yang Photocyclization/1,2-Methyl Migration: Scope and limitations

Poly-substituted 2-hydroxycyclobutanone motifs are core motifs in many biologically important natural products, we recently developed Norrish–Yang photocyclization/1,2-methyl migration as a synthetic strategy for regio/stereoselectively constructing them and profiled the scope and limitations of the proposed strategy in this work.