过量服用氯氮平和氯丙嗪中毒的精神分裂症1例急救护理
Chinese Journal of Rural Medicine and Pharmacy(2021)
Abstract
氯氮平和氯丙嗪均是非典型抗精神病药,常用于治疗难治性精神分裂症.此类药对脑内5-羟色胺和多巴胺能受体有较强的阻滞作用,还有抗胆碱能、抗组胺等作用,能抑制脑干网状结构上行激活系统,有强大的镇静、催眠效果.其口服吸收快而完全,50%~60%的肝脏首过效应,半衰期平均9小时,体内蛋白结合率高达90%以上.
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