乙蒜素缓释凝胶剂的制备研究
Guangdong Chemical Industry(2021)
Abstract
为了制备持效期长的乙蒜素缓释凝胶剂,筛选了乙蒜素相容和不相容油芯材料,优化了复合油芯材料配方,制备了固化凝胶,并测定了乙蒜素的释放周期.结果表明,PETS和PETO能与乙蒜素混溶,吐温80、PEDS和PEDO不能与乙蒜素混溶.PETS和PEDO质量比4∶1下,熔融相变温度为45℃.乙蒜素含量8%的凝胶颗粒20℃和35℃下10 d释放率分别为18.0%、99.5%.通过油芯和凝胶化包埋,大幅延长了乙蒜素释放周期.
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