HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

Background Human papillomavirus (HPV) infection can cause a variety of epithelial lesions, including even various malignant cancers, such as cervical cancer, vulvar cancer and etc. Most cervical cancers were closely associated with HPV infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing vaccination effects. Aim This study was designed to investigate HPV infection prevalence and genotype distribution among women from Hengyang district of Hunan province in China.Methods A total of 12053 patient data from the three-level hospitals in Hengyang city between July 2016 and July 2017 were retrospectively analyzed. The HPV positive was identified by Polymerase chain reaction (PCR). The HPV PCR-Flow fluorescence assay was used for HPV genotyping. The Chi-square test was performed to compare the differences among HPV infection rates or HR-HPV ratio-in-positives.Results In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in a descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The patients who were above 60 years and below 21 years old were the most and second HPV prevalent group, respectively, the corresponding HR-HPV infection rates were the most and the third, respectively. The infection rates of HPV and HR-HPV among outpatients were lower than those among hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among 50~60 years group were both the most, following by those among above 60 years group. The HR-HPV ratio-in-positive among HPV-positive patients with histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%.Conclusions This study demonstrated that the HPV prevalence varied with the age among women from Hengyang district of Hunan province in China and showed their HPV genotype distribution that HPV16, HPV58, HPV52, HPV39, HPV51 and HPV53 infection were more popular in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.