Alteration of circulating natural antibodies against VEGFR1-derived peptide antigens in atherosclerosis
semanticscholar(2020)
Abstract
Background Several lines of evidence suggest the protective role of natural antibody in common chronic disease like atherosclerosis and cancer. Vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2) are important regulators of angiogenesis and their involvement in developing atherosclerosis cannot be ruled out. Purpose The present study was designed to develop an in-house enzyme-linked immunosorbent assay to test if natural IgG for VEGFR1 and regulatory T cell markers CD25 and FOXP3 could be associated with atherosclerosis. Methods A total of 218 patients with atherosclerosis and 200 healthy controls were recruited; all patients had atherosclerotic carotid plaque and carotid intima–media thickness was analyzed using a diagnostic ultrasound system. Results Mann-Whitney U test demonstrated that plasma anti-VEGFR1 IgG levels were significantly lower in atherosclerosis patients than control subjects (Z=-2.46, P =0.014) although neither anti-CD25 IgG levels nor anti-FOXP3 IgG levels showed significant changes. Male patients mainly contributed to the decreased antiVEGFR1 IgG levels (Z=-2.45, P =0.014). Spearman correlation analysis failed to show any significant correlation between natural IgG levels and carotid intima–media thickness. Conclusion Decreased levels of anti-VEGFR1 IgG may be involved in developing atherosclerosis-related conditions.
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Key words
atherosclerosis,natural antibodies,peptide antigens
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