Extracellular Vesicles and Circulating Nucleic Acids

Ryan P. McNamara, Hannah M. McMillan, Blanca V. Rodriguez, James, Erickson,Heather Branscome,Sarah Al Sharif, Ribhav Mishra, Kathleen M Lennon,Amy H. Lee, C. Jean, Lee,Bridget Ratitong,Jessica Pullan, Joshua L. Hood,Janos Zempleni,Jordan Pavlic, Nicole Noren Hooten, Sarah F. Andres, Lisa Meyer,Shivani Sharma, Johnny, Akers,Laura Perin, Emma Purcell,Tatsuo Kurihara, Shamba Gupta,Ikuhiko Nakase,Ryan Reshke, Tsuneya Ikezu, Hameeda Sultana, Killian P. O’Brien, Chukwumaobim, D. Nwokwu, Inge S. Zuhorn,Simon Carding,Dennis A. Steindler,Frederik J. Verweij, Crislyn D’Souza-Schorey,Moran Amit

semanticscholar（2021）

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摘要

s: Argonaute 2 (Ago2) is the essential component of the RNA-Induced Silencing Complex (RISC) that binds miRNAs and promotes mRNA degradation. Extracellular vesicle (EV)-carried miRNAs have been shown to influence gene expression and functional phenotypes in recipient cells. Many investigators have found Ago2 in EVs and it is postulated that Ago2 is a major transporter of miRNAs into small EVs (SEVs), such as exosomes. Others have reported that extracellular Ago2 is nonvesicular. I will discuss issues that may lead to diverging results and show data on the role of culture conditions in the detection of Ago2 in SEVs. Page 22 Extracell Vesicles Circ Nucleic Acids 2020;1:20-56 I http://dx.doi.org/10.20517/evcna.2020.10

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