Recognition of antigens by nanobodies from structural and energetic viewpoints

Jose M.M. CAAVEIRO,1,2,* Hiroki AKIBA,2,3 Hiroko TAMURA,4 and Kouhei TSUMOTO2,3,4,5,* 1 Global Healthcare, Grad. School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, 812-8582 Japan 2 Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan 3 Laboratory of Pharmacokinetic Optimization, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka, 567-0085 Japan 4 Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-31 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan 5 Medical Proteomics Laboratory, The Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8629 Japan.