Reduced CXCR4 expression in associated with extramedullary and predicts poor survival in newly diagnosed multiple myeloma.
Expert review of hematology（2022）
Abstract
The incidence of extramedullary lesions in CXCR4-negative patients increased significantly compared with CXCR4-positive patients. Plasma cells that reduce CXCR4 expression have poor prognosis and increase the incidence of extramedullary lesions.
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Key words
CXCR4,Multiple myeloma,extramedullary lesions,new diagnosis,prognostic biomarker
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