Snapping out of Autopilot: Overriding Habits in Real Time and the Role of Ventrolateral Prefrontal Cortex

Habits allow environmental and interoceptive cues to trigger behavior in an automatized fashion, making them liable to deployment in inappropriate or outdated contexts. Over the long-term, repeated failure of a once adaptive habit to satisfy current goals produces extinction learning that suppresses the habit’s execution. Less attention has been afforded to the mechanisms underlying real-time habit suppression: the capacity to stop the execution of a cued habit that is goal-conflicting. Here, we first posit a model by which goal-relevant stimuli can 1) bring unfolding habits and their projected outcomes into awareness, 2) prompt evaluation of the habit outcome with respect to current goals, and 3) trigger cessation of the habit response if it is determined to be goal-conflicting. Second, we propose a modified stop-signal task to test this model of “goal-directed stopping of habit execution”. Finally, we marshal evidence indicating that the ventrolateral prefrontal cortex (vlPFC), situated at the nexus of salience detection, action-plan assessment, and motor inhibition networks, is uniquely positioned to coordinate the overriding of habitual behaviors in real time. In sum, this review presents a testable model and candidate neurobiological substrate for our capacity to “snap out of autopilot” and override goal-conflicting habits in real time.