TICB 1312 No . of Pages 14

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, and Medical Research Institute, Wuhan University, Wuhan, Hubei, 430072, China 2 [177_TD$DIFF] aihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA