Case Study: Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient

Jonathan Klein*1, Anderson F. Brito*2, Paul Trubin*3, Peiwen Lu*1, Patrick Wong1, Tara Alpert2, Mario A. Peña-Hernández4, Winston Haynes5, Kathy Kamath5, Feimei Liu1, Chantal B. F. Vogels2, Joseph R. Fauver2, Carolina Lucas1, Jieun Oh1, Tianyang Mao1, Julio Silva1, Anne L. Wyllie2, M. Catherine Muenker2, Arnau Casanovas-Massana2, Adam J. Moore2, Mary E. Petrone2, Chaney C. Kalinich2, Yale IMPACT Research Team10, Charles Dela Cruz6, Shelli Farhadian7, Aaron Ring1, John Shon5, Albert I. Ko2,3, Nathan D. Grubaugh2,8, Benjamin Israelow1,3,†, Akiko Iwasaki*1,9,††, Marwan M. Azar*3,†† 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. 2Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. 3Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA. 4Department of Biological and Biomedical Sciences, Yale University School of Medicine, New Haven, CT, USA. 5Serimmune Inc., Goleta, CA, USA 6Department of Medicine, Section of Pulmonary and Critical Care Medicine; Yale University School of Medicine, New Haven, CT, USA. 7Department of Internal Medicine, Section General Medicine; Yale University School of Medicine, New Haven, CT, USA. 8Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA. 9Howard Hughes Medical Institute, Chevy Chase, MD, USA. 10A list of members and their affiliations appears at the end of the paper (Supplementary List 1). *These authors contributed equally Senior Corresponding Author††: A.I. (akiko.iwasaki@yale.edu) Clinical Corresponding Author††: M.A. (marwan.azar@yale.edu) Corresponding Author†: B.I. (benjamin.goldman-israelow@yale.edu) All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted March 26, 2021. ; https://doi.org/10.1101/2021.03.24.21253992 doi: medRxiv preprint